Featured Publications

To learn more about the "Supersensitivity" book and "Cannon's Law"
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Cannon's Law

Normal nerve and muscle depend upon intact innervation to provide regulatory or "trophic" effect. It has been shown that any measure which blocks the flow of motor impulses and deprives the effector organ of excitatory input for a period of time can cause "disuse supersensitivity" in that organ, as well as in associated spinal reflexes. Supersensitive nerves and innervated structures react abnormally to stimuli according to Cannon and Rosenblueth’s law of denervation:

"When a unit is destroyed, in a series of efferent neurons, an increased irritability to chemical agents develops in the isolated structure of structures, the effect being maximal in the part directly denervated."

That means, when a nerve is functioning below par and is not functioning properly (neuropathy), it becomes supersensitive and behaves erratically. This principle is fundamental and universal, yet is not well-known or credited. Peripheral neuropathy parallels the aging process, most intense at the weight-bearing and mobility areas of the body.

REF: iSTOP Legacy Website 

Articles which cite "Cannon's Law"

PAIN: A Comprehensive Definition

Intramuscular Stimulation (IMS) - The Technique

Neuropathic Myofascial Pain Syndromes

"Prespondylosis" and some Pain Syndromes Following Denervation Supersensitivity

Radiculopathic Pain: Diagnosis And Treatment Of Segmental Irritation or Sensitization

To learn more about the "Wisdom" book
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"Chronic disease, whether it be hypersensitivity, or chronic degenerative disease, or a combination, prevails and should now be the basis of thinking for all physicians, scientists, and lay people in society".

Reversibility of Chronic Degenerative Disease and Hypersensitivity

William J Rea and Kalpana Patel

Volume 1Volume 2Volume 3Volume 4Volume 5

To learn more about the "Reversibility" volumes click here

“Thanks to all the great anatomists and physiologists of the ages, especially... 

Chan Gunn, MD... and many others whose ideas and facts we used liberally to solidify the concepts of hypersensitivity and chronic degenerative disease”.

Our gratitude goes out to all iSTOP members and donors for making this directory possible. 

Thank you for making GunnIMS resources available to the public, for patients, practitioners, researchers and enthusiasts alike.

Gunn IMS "points" the way!

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