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Supersensitivity of the Denervated Structures
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| Dr. Gunn often quotes this publication to highlight “Cannon’s Law” Cannon's Law: Normal nerve and muscle depend upon intact innervation to provide regulatory or "trophic" effect. It has been shown that any measure which blocks the flow of motor impulses and deprives the effector organ of excitatory input for a period of time can cause "disuse supersensitivity" in that organ, as well as in associated spinal reflexes. Supersensitive nerves and innervated structures react abnormally to stimuli according to Cannon and Rosenbleuth's law of denervation: "When a unit is destroyed, in a series of efferent neurons, an increased irritability to chemical agents develops in the isolated structure of structures, the effect being maximal in the part directly denervated." That means, when a nerve is functioning below par and is not functioning properly (neuropathy), it becomes supersensitive and behaves erratically. This principle is fundamental and universal, yet is not well-known or credited. Peripheral neuropathy parallels the aging process, most intense at the weight-bearing and mobility areas of the body. The Supersensitivity Of Denervated Structures: A Law Of Denervation Authors
2013 - Published by Literary Licensing, LLC, United States Preview Index ISBN Search by title or ISBN to compare price for new & used books This publication is available for educational purposes Shareable Link (preview) REF: iSTOP Legacy Website Publications in which Dr. Gunn cites "Cannon's Law" PAIN: A Comprehensive Definition Intramuscular Stimulation (IMS) - The Technique Neuropathic Myofascial Pain Syndromes "Prespondylosis" and some Pain Syndromes Following Denervation Supersensitivity Radiculopathic Pain: Diagnosis And Treatment Of Segmental Irritation or Sensitization |
Citations - Cannon's Law
| Author(s) | Title | Keywords | DOI / ISBN | Download | ||
| Gunn, C. Chan | The Gunn Approach to the Treatment of Chronic Pain - Intramuscular Stimulation for Myofascial Pain of Radiculopathic Origin |
Denervation & Cannon's Law | 9780443054228 |
PDF Download |
1989-2007 | iSTOP Publications |
Ganzel, Morris, Wethington |
Allostasis and the Human Brain: Integrating Models of Stress From the Social and Life Sciences |
Walter Cannon and Homeostasis general adaptation syndrome (GAS) Three stressor stages alarm stage resistance exhaustion neurotransmitters and neurohormones |
10.1037/a0017773 |
PDF Download |
2010 | ResearchGate |
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Heather Tick, M.A. M.D. and Eric B. Schoomaker, MD, PhD, Richard H. Carmona and Mark Liponis |
Chapter 21: Transforming Pain Management Through the Integration of Complementary and Conventional CareBook: Integrative Preventive Medicine |
Peripheral and central sensitization can be co-occurrent, Cannon's work overlooked in current conversations about sensitization. pg 501 |
9780190241254 019024125X |
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2018 |
preview |
| F. R. Hunter | Book Review: The Supersensitivity of Denervated Structures by W. B. Cannon, A. Rosenbleuth |
theories and implications of this "law of denervation" |
Vol. 20, No. 3 (Oct., 1949), pp. 200-202 (3 pages) |
Beta Biological Society |
1949 | By request
educational use |
| Mullins, Jennifer F; Nitz, Arthur J; Hoch, Matthew C | The Effect of Dry Needling on Patient Reported Outcomes in Individuals with Chronic Ankle Instability: A Critically Appraised Topic |
Human Kinetics Journals. Department of Rehabilitation Sciences, University of Kentucky, Lexington, K | 10.1123/ijatt.2018-0075 | HKJ | 2019 | |
| Mullins, Jennifer F; Hoch, Matthew C; Nitz, Arthur J | Novel Application of Dry Needling for Neuropathic Myofascial Ankle Pain and Dysfunction Following Insidious Integumentary Infection: A Case Report |
Elsevier | 10.1016/j.jbmt.2019.10.017 | JBMT | 2019 |