The Institute for the Study and Treatment of Pain

Featured Publications

The Supersensitivity of Denervated Structures

"Cannon's Law"

Walter B Cannon & Arturo Rosenblueth

Normal nerve and muscle depend upon intact innervation to provide regulatory or "trophic" effect. It has been shown that any measure which blocks the flow of motor impulses and deprives the effector organ of excitatory input for a period of time can cause "disuse supersensitivity" in that organ, as well as in associated spinal reflexes. Supersensitive nerves and innervated structures react abnormally to stimuli according to Cannon and Rosenblueth’s law of denervation:

"When a unit is destroyed, in a series of efferent neurons, an increased irritability to chemical agents develops in the isolated structure of structures, the effect being maximal in the part directly denervated."

That means, when a nerve is functioning below par and is not functioning properly (neuropathy), it becomes supersensitive and behaves erratically. This principle is fundamental and universal, yet is not well-known or credited. Peripheral neuropathy parallels the aging process, most intense at the weight-bearing and mobility areas of the body.

READ "Cannon's Law"

The Wisdom of the Body

Author: Walter Bradford Cannon

This book includes information about the regulation of body fluids, thirst, hunger, temperature, oxygen supply, sugar, water, and body proteins. It also discusses the role of the sympathetic-adrenal mechanism.


Commentary on the Effect of Electricity on Muscular Motion

by Robert Montraville Green, MD

A Translation of Luigi Galvani's De Viribus Electricitatis



Trigger Point Dry Needling

Authors: Jan Dommerholt & Cesar Fernandez de las Penas

Co-Authors: Steven Goodman MD & Cory Choma PT


Volume 1Volume 2Volume 3Volume 4Volume 5

Reversibility of Chronic Degenerative Disease and Hypersensitivity
William J Rea and Kalpana Patel

"Chronic disease, whether it be hypersensitivity, or chronic degenerative disease, or a combination, prevails and should now be the basis of thinking for all physicians, scientists, and lay people in society".


The Gunn Approach to the Treatment of Chronic Pain: Intramuscular Stimulation for Myofascial Pain of Radiculopathic Origin

Author: Dr. C. Chan Gunn

Translated into several languages and distributed internationally.

Languages: English, Chinese, Korean, Japanese, German

This book is essential reading for physiotherapists, sports medicine therapists, massage therapists, as well as medical doctors involved in pain therapy. It is used as base prerequisite reading material for IMS courses worldwide.



Our gratitude goes out to all iSTOP members and donors since 1994. 

Thanks to you Gunn intramuscular stimulation information resources are freely available to
the public, for patients & their family members, CGIMS certified practitioners, health advocates, pain researchers and enthusiasts alike.

Gunn IMS "points" the way!

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